Biochem.Pharmacol. A yearlong study gave 130 women with breast cancer on tamoxifen therapy either a placebo or 150 mg of DIM twice a day. The first section provides a quick guide to using the Dim statement including examples and the format of the Dim statement. Am.J.Pathol. View abstract. A controlled safety study of diindolylmethane in the immature rat model. Although research on DIM is still quite limited, it’s thought to help balance estrogen levels in your body (1). Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., and van den Berg, M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Carcinogenesis 2001;22(11):1809-1817. Indole-3-carbinol. Furthermore, DIM supplements may stimulate fat breakdown and inhibit fat cell formation. Current human research doesn’t show DIM supplements to be toxic or have serious side effects. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. View abstract. Inflamm.Bowel.Dis. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. But this does not mean that DIM is always safe in supplemental form. 11-25-2005;337(3):1019-1025. The body must convert Indole-3-carbinol into DIM to utilize it. Case Rep Med. As a result, people looking to treat a specific condition like acne or prostate issues may seek a concentrated dose in the form of a DIM supplement. 2006;15(12):2477-2481. 2006;17(10):659-664. 2004;18(2):291-302. 1993;46(6):791-798. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. 2001;61(1):40-48. View abstract. Just click and drag it to your active character. Due to insufficient evidence, dosage information for DIM is lacking. This article reviews 12 actions you can take to help your hormones function optimally. View abstract. Jin, Y., Zou, X., and Feng, X. Mol Cancer Ther. DIM is a compound your body creates when you eat cruciferous vegetables. Something may be wrong with it, or with your browser (maybe you have a content blocker, or have disabled JavaScript, or your browser is too … Tadi, K., Chang, Y., Ashok, B. T., Chen, Y., Moscatello, A., Schaefer, S. D., Schantz, S. P., Policastro, A. J., Geliebter, J., and Tiwari, R. K. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. | Livestrong.com View abstract. 2003;133(4):1011-1019. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Learn how to identify the symptoms, what causes it, and more. CONDITIONS OF USE AND IMPORTANT INFORMATION: In one study in mice on a high fat diet, 23 mg of DIM per pound (50 mg per kg) of body weight significantly reduced the formation of new fat cells (19). View abstract. B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Aggarwal, B. Uncontrolled Blood Sugar: How Dangerous Is It? Gear. Gynecol.Oncol. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. 5-1-2006;66(9):4880-4887. However, human studies are limited (1, 2). Cancer of the cervix. Test-tube and animal studies indicate that DIM protects against ovarian, prostate, and colon cancers as well. Low estrogen is typically seen in younger women and women approaching menopause. © 2005-2021 Healthline Media a Red Ventures Company. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. 2006;19(3):436-442. Proponents claim that consuming diindolylmethane can help increase your defense against several types of cancer, as well as promote detoxification and support weight loss. 2009;139(1):26-32. Anticancer Res. We’ll go over 7 science-backed PMS supplements that may provide relief for both physical and…, ER-positive breast cancer is the most common type of breast cancer diagnosed today. This article provides a comprehensive overview of DIM supplements, including their benefits and side effects. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. Cancer Res. At this time there is not enough scientific information to determine an appropriate range of doses for diindolylmethane. Q: What is DIM?A: DIM stands for diindolylmethane, which is a molecular compound found in vegetables from the cruciferous vegetable family. Kim, E. J., Park, H., Kim, J., and Park, J. H. 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. As it affects estrogen levels, DIM may help treat a … Chang, X., Tou, J. C., Hong, C., Kim, H. A., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Chen, Y., Xu, J., Jhala, N., Pawar, P., Zhu, Z. 3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells. Carcinogenesis 2005;26(4):771-778. 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis. View abstract. Kandala, P. K. and Srivastava, S. K. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. A DIM supplement is a nutritional supplement composed of a phytochemical that our body naturally produces by breaking down a compound in our diet. Taking diindolylmethane along with some medications that are changed by the liver can decrease the effectiveness of some medications. View abstract. Nachshon-Kedmi, M., Yannai, S., Haj, A., and Fares, F. A. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. A Indolplex is an over-the-counter supplement containing an extract of diindolylmethane (DIM), a chemical found in cruciferous vegetables, such as broccoli, Brussels sprouts, cauliflower, and cabbage. Need those STOMP-EE5 for the jumping puzzle? Therefore, it’s best to talk to your healthcare provider to obtain personalized dosage recommendations based on your intended use. 5-15-2006;132(2):208-213. View abstract. 1-15-2009;15(2):543-552. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. 2010;2(4):402-411. McDougal, A., Gupta, M. S., Morrow, D., Ramamoorthy, K., Lee, J. E., and Safe, S. H. Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage, and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. Smith, T. K., Lund, E. K., Clarke, R. G., Bennett, R. N., and Johnson, I. T. Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro. Intriguingly, observational studies associate high cruciferous vegetable intake with a reduced risk of certain cancers, including breast and prostate cancer. Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. 2008;138(12):2379-2385. The KING of dim sum, the har gao, is the benchmark of any dim sum restaurant in Southern China. Azmi, A. S., Ahmad, A., Banerjee, S., Rangnekar, V. M., Mohammad, R. M., and Sarkar, F. H. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM). Balk JL. Ann N Y Acad Sci 1999;889:204-13. Hong C, Firestone GL, Bjeldanes LF. View abstract. View abstract. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. J Allergy Clin Immunol Pract. Proof by scientific studies and the only brand medical practitioners can trust. What factors influenced or will influence your purchase? 2009;139(12):2373-2379. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. They’re also used to help prevent prostate enlargement, treat acne, aid weight loss, and reduce premenstrual syndrome (PMS) and menopause symptoms. DIM stands for diindolymethane, a natural compound found in cruciferous vegetables, including cabbage, broccoli, cauliflower, kale, Brussels sprouts and more. Carcinogenesis 2005;26(11):1896-1904. View abstract. J.Nutr. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. View abstract. Chicken's feet. 3-15-2002;63(6):1085-1097. Kotsopoulos J, Zhang S, Akbari M, Salmena L, Llacuachaqui M, Zeligs M, Sun P, Narod SA. Li, Y., Li, X., and Guo, B. Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Vivar, O. I., Lin, C. L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. A way to remedy excess estrogen is to try…, Men trying to manage their testosterone levels may turn to estrogen blockers to help balance their hormones. 3,3'-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells. Mol.Endocrinol. View abstract. View abstract. Thyroid. As DIM supplements interact with estrogen levels, they may affect people with hormone-sensitive cancers or who are on hormone therapies. Laryngoscope 2009;119(9):1803-1808. 2008;7(6):1708-1719. 2008;138(1):17-23. View abstract. Biochem Pharmacol. Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect. Dim [ WithEvents ] varname [ ( [ subscripts ] ) ] [ As [ New ] type ] [ , [ WithEvents ] varname [ ( [ subscripts ] ) ] [ As [ New ] type ]] . Create the perfect loadout for Raids, Strikes, Gambit, and any other loadout that would be helpful. It is being studied for its anticancer properties DIM supplements contain diindolymethane, which is found in cruciferous vegetables like broccoli and cabbage. View abstract. Therefore, DIM is a bio-available metabolite of I3C. A., and Kim, Y. S. Estrogen receptor alpha as a target for indole-3-carbinol. 9-1-2009;78(5):469-476. Sasieni, P. Chemoprevention of cervical cancer. View abstract. 3,3’-diindolylmethane (DIM) 2. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Visual Basic supports a variety of variable types. Carcinogenesis 2006;27(4):717-728. J Pharmacokinet Pharmacodyn. Cancer Detect.Prev. Toxicol.Sci. Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. J.Nutr. J.Cell Biochem. Still, you may wonder whether these uses are backed by scientific evidence. View abstract. Before taking diindolylmethane talk to your healthcare provider if you take any medications that are changed by the liver.Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. Hsu, J. C., Zhang, J., Dev, A., Wing, A., Bjeldanes, L. F., and Firestone, G. L. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. View abstract. We declare a variable to a specific data type in VBA we use the DIM keyword to do it. Cancer Epidemiol.Biomarkers Prev. 1978;38(5):1410-1413. Zhao, Y. Y., Zhou, L., Pan, Y. 6-6-2003;278(23):21136-21145. View abstract. They are usually stir-fried or deep-fried, then marinated, and finally, … The appropriate dose of diindolylmethane depends on several factors such as the user's age, health, and several other conditions. 1-15-2010;70(2):646-654. In preliminary research, some scientists have found that diindolylmeth… 2008;25(9):2117-2124. While these benefits are promising, overall research on DIM’s effectiveness and long-term safety in humans is limited. View abstract. Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. View abstract. Cancer Res. 7-20-2007;282(29):21542-21550. 3-9-1993;45(5):1129-1136. View abstract. 1999;19(4B):3199-3203. View abstract. 2002;132(11):3314-3324. Where did you or where do you plan to purchase this product? Br J Cancer. View abstract. View abstract. Gamet-Payrastre, L., Lumeau, S., Gasc, N., Cassar, G., Rollin, P., and Tulliez, J. Additionally, DIM has been shown to inhibit an enzyme called aromatase, which converts testosterone to estrogen (1). Diindolylmethane (DIM) is an exciting supplement that gives women a natural option to help with estrogen dominance, which causes many of our female troubles. While more research is needed, it’s thought to help balance hormone levels via its effects on estrogen. Find out what ER-positive breast cancer means and learn about…, Men who are experiencing low testosterone, or “low T,” often have elevated levels of the hormone estrogen. Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., and Safe, S. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. View abstract. DIM blocks the effects of testosterone. 2016;2016:7527098. In a 12-month study, 21 men with high-grade PIN were given either a placebo or 900 mg of DIM per day. 2002 Mar 15;63(6):1085-97. The Dimstatement syntax has these parts: as the brightness is increased, the levels keep going back down as the brightness is turned up. Still, it’s important to remember that research is lacking on all of these effects. Biochem Pharmacol 1996;51:1069-76. However, their effectiveness for other hormone-related conditions hasn’t been widely studied. The Dim command also allocates an appropriate amount of memory for the computer to store the value of the variable. View abstract. As a result, DIM supplements have been gaining popularity as a potential treatment for a variety of hormone-related conditions, including acne, menopause symptoms, prostate issues, and certain forms of cancer. Due to a lack of research in humans, little is known about the long-term safety and side effects of DIM supplements. All rights reserved. 2003;41(6):745-752. 2001;66(2):147-157. Cancer Res. J Nutr 2003;133(7 Suppl):2448S-2455S. Elackattu, A. P., Feng, L., and Wang, Z. (check all that apply), What factors are most important to you? 7-1-2007;67(13):6502-6511. Kim, Y. H., Kwon, H. S., Kim, D. H., Shin, E. K., Kang, Y. H., Park, J. H., Shin, H. K., and Kim, J. K. 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Rahman, K. W., Li, Y., Wang, Z., Sarkar, S. H., and Sarkar, F. H. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Best.Pract.Res.Clin.Obstet.Gynaecol. 2001;131(12):3294-3302. All rights reserved. 3'3-diindolylmethane induces apoptosis in human cancer cells. 9-1-1999;58(5):825-834. Chen, D. Z., Qi, M., Auborn, K. J., and Carter, T. H. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. DIM is a compound your body makes from cruciferous vegetables. 2014 Sep 23;111(7):1269-74. Oncogene 3-31-2005;24(14):2343-2353. Biochem.Pharmacol. DIM Plus does not contain artificial colors, preservatives, or sweeteners and is gluten-free, lactose-free, soy-free, and non-GMO. View abstract. BioResponse DIM® for healthy estrogen for women and men Highly bioavailable microencapsulated DIM Complex with guaranteed, proven absorption. J.Nutr. View abstract. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Before taking these supplements, get dosage guidance from your healthcare provider. What Are the Symptoms of Low Estrogen in Women and How Are They Treated? This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. It is popular as a dietary supplement and is claimed to be useful for a variety of different purposes, most of which are related to estrogen metabolism or cancer. There’s no hard and fast rule on when to eat dim sum, but it’s typically eaten in the morning to afternoon. View abstract. Chang, Y. C., Riby, J., Chang, G. H., Peng, B. C., Firestone, G., and Bjeldanes, L. F. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. (check all that apply). View abstract. View abstract. Cancer Epidemiol.Biomarkers Prev. All the same, human studies are needed (10, 11, 12). DIM supplements resulted in a significantly improved ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone (8). Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. Breast Cancer Res.Treat. View abstract. However, in a 6-month study in 551 women with cervical abnormalities, taking 150 mg of DIM per day had no effect on cervical cell changes (3, 13). Biochem.Biophys.Res.Commun. Degner, S. C., Papoutsis, A. J., Selmin, O., and Romagnolo, D. F. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. Leong, H., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. This post provides a complete guide to using the VBA Dim statement. A. Ge, X., Fares, F. A., and Yannai, S. Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. Bhuiyan, M. M., Li, Y., Banerjee, S., Ahmed, F., Wang, Z., Ali, S., and Sarkar, F. H. Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Staub, R. E., Onisko, B., and Bjeldanes, L. F. Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. Healthline Media does not provide medical advice, diagnosis, or treatment. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? “DIM can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing TPD.” Evidence of DIM having a positive effect on the thyroid is visible in another study that set out to analyze the impact of DIM on the invasion of thyroid cells. 2010;78(2):297-309. Leong, H., Firestone, G. L., and Bjeldanes, L. F. Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. Cruciferous vegetables are low-calorie, and rich in folate, vitamins C, E, and K, and fiber. View abstract. Wu TY, Huang Y, Zhang C, Su ZY, Boyanapalli S, Khor TO, Wang H, Lin H, Gounder M, Kagan L, Androulakis IP, Kong AN. Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Test-tube and animal studies likewise suggest that DIM helps fight prostate cancer. View abstract. Yerushalmi R, Bargil S, Bar Y, et al. View abstract. Last medically reviewed on July 22, 2020. Chemicals may seem like the best route for acne-prone skin, but it’s not your only option. View abstract. View abstract. Have you ever purchased DIINDOLYLMETHANE? J.Agric.Food Chem. J.Nutr.Biochem. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. View abstract. Weapons. 5-18-2005;53(10):3895-3901. View abstract. View abstract. View abstract. When the physical brightness controls buttons (for the monitors) are used, there is something happening that fights the use of these buttons (i.e. As it affects estrogen levels, DIM may help treat a variety of conditions, including hormone-sensitive cancers and prostate issues. Am.J.Transl.Res. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DIINDOLYLMETHANE. Carcinogenesis 2010;31(9):1634-1641. Keep in mind that natural products are not always necessarily safe and dosages can be important. DIM supplements are purported to aid other hormone-related conditions. Uses and potential benefits of DIM supplements, Cruciferous Vegetables: Health Benefits and Recipes. Ichite, N., Chougule, M. B., Jackson, T., Fulzele, S. V., Safe, S., and Singh, M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. 2006;20(2):295-305. Cancer Res. Li, Y., Li, X., and Sarkar, F. H. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. Notably, a mouse study found that DIM helped prevent cervical cancer. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. View abstract. For each shipment, you are charged based on the dimensional weight or actual weight of the package—whichever is greater. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, PMS Supplements: 7 Options for Mood Swings and Other Symptoms, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, ER-Positive Breast Cancer: Prognosis, Life Expectancy, and More, 7 Foods for Lowering Estrogen Levels in Men, Natural and Pharmaceutical Estrogen Blockers for Men, 12 Natural Ways to Boost Estrogen in Your Body, Breast Cancer Hormone Therapy: How It Works, Side Effects, and More, Our Favorite Healthy Finds: Organic Beauty Products for Acne-Prone Skin. It’s been heavily researched as a possible anticancer compound, and appears to exert estrogen blocking effects in some studies as well. Fight zits and skin damage with all-natural, organic…. View abstract. Ali, S., Banerjee, S., Ahmad, A., El-Rayes, B. F., Philip, P. A., and Sarkar, F. H. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Biochem.Pharmacol. Firestone, G. L. and Bjeldanes, L. F. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. In human research, doses typically range from 108–900 mg per day — though these studies were only related to treatments for cancer and prostate enlargement (8, 9, 14). Fire up DIM and grab them. Test-tube and animal studies suggest that DIM supplements may help prevent the growth and spread of breast cancer cells. DIM (diindolylmethane) is a breakdown product of indole-3-carbinol, a compound found in broccoli, cauliflower, cabbage, brussels sprouts, and other cruciferous vegetables. 11-1-2009;108(4):916-925.
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